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Blood Lipid Fractions 3/3 HDL


Medical Center, Dr. Michalak Underground Medicine Newsletter ----- -----

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*** *** Blood Lipid Fractions Part 3/3: HDL

This is a faction that is produced by the liver and intestine. It fulfills two main tasks.

First, is the main transport of cholesterol from peripheral tissues and other plasma lipid fractions (VLDL, chylomicrons), for liver. It is like a bag, which after the expulsion and blood is empty, then circulates through the body and collects cholesterol, the filled with content to throw their liver cells and returns empty into circulation. In the end is removed entirely by the liver.

The second important role of these particles is to store the inventory of particles protein, called. apolipoproteins (apoA, APOC and apoE). These are proteins which are essential for the proper transmission of the tissues triglycerides, cholesterol and phospholipids from other factions lipid. There are also important in removing LDL and chylomicron remnant by the liver. Chylomicrons and VLDL produced in the gut and liver do not have on its surface of all these proteins. They are transferred from HDL only after penetration into the blood. These proteins are moved back to the remnants of chylomicrons from HDL and LDL before their removal from the blood by the liver.

Free fatty acids (PUFA)

Speaking of fat in the body economy can not ignore the role of free fatty acids (PUFA). Not yet written in simple, that the triglycerides of chylomicrons and VLDL are transported to tissues peripheral. In fact, it looks that the external cell surfaces of most peripheral tissues are the enzyme lipoprotein lipase. It is a protein which bind to chylomicrons and VLDL particles. In doing so, connection comes to the distribution of those particles triglycerides into glycerol and free fatty acids. Glycerol gets into the blood, penetrates into cells that possess the enzyme protein kinase glycerol, and there is burnt. Fatty acids are the most immediately transported into the cell, but some remains in the blood and reaches out to other tissues, which utilizes them as fuel.

Certainly seem strange to all that the concentration of free fatty fats in the blood is low in a high state of satiety can starvation. This is because the amount of blood depends mainly on how much they shall arise, and most of them formed during the famine. Then they are released in large part to the fat stores in the tissue fat. A rapid increase of free fatty acids also occurs in decompensated diabetes, since insulin inhibits the formation. This causes an uncontrolled release of their adipose tissue. Because they can not be completely burned, some of them converts to the so-called liver. ketone bodies.

Part of LCP after absorption into the tissue can be re-connected glycerol, which is set aside in reserve. This phenomenon occurs most in muscle and heart, where access to fast fuel is needed. In a small degree of LCP can also be absorbed into the tissue fat, however, note that adipose tissue does not contain a kinase glycerol, or glycerol must itself be prepared from sugar. Manufacture glycerol may occur only under conditions of satiety, and in these conditions FFA concentration in serum is low. Nevertheless, in some people fat intake may influence the rate of weight loss, and even cause weight gain. It is necessary then limiting fat intake. Fundamentally, however remember that adipose tissue is synthesized mainly from SUGAR.

tbc ...

MD Piotr Krzysztof Michalak ---- To receive the Newsletter, please visit and Enter your email address. --- If you believe that someone of your friends would add to the information from this Bulletin - send it to him now that e-mails ... ---
Blood Lipid Fractions 3/3 HDL

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